Ingredient Spotlight: Pterostilbene, Next Generation Resveratrol

We see great potential for creating custom nutritional supplements using the potent antioxidant pterostilbene, offering health benefits ranging from anti-aging, heart health, oxidative stress and memory.  Because of its better absorption and ability to last up to 7 times longer in the body than resveratrol, current science supports lower a daily dosage create an opportunity to include other key nutrients within the same supplement.

You may already know…

Resveratrol is a naturally occurring plant polyphenol commonly found in grape vines and skins.  Highly regarded as a powerful antioxidant, it plays supporting roles in normal cardiovascular and mitochondrial function.  Studies also indicate resveratrol may be supportive in maintaining the normal aging process by helping to prevent free radical damage that can lead to premature aging of cells.

But are you aware…

Pterostibene is a methylated resveratrol that is naturally occurring in berries.  Some advantages over resveratrol include:

  • Superior biological activity
  • Better oral bioavailability
  • Slower metabolism in the body

The enhanced activity of pterostilbene compared to resveratrol may be explained by structural differences.  Pterostilbene with two methoxy groups and one hydroxyl group has a greater ability to dissolve in fats, oils, lipids and non-polar solvents, and a higher potential for cellular uptake than resveratrol, which has three hydroxyl groups.

Pterostilbene also supports cardiovascular health.  In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects.

Two may be better than one!

Both pterostilbene and resveratrol support mitochondrial function and healthy aging by activating SIRT1, a key enzyme in a family of proteins that have been associated with influencing aging, energy efficiency, and alertness during low-calorie intake.

Researchers have suggested that these two compounds also work synergistically.  The combination of pterostilbene and resveratrol in a formulation may in fact be more effective than using these ingredients separately.

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